DetermaDxTM is a liquid biopsy test intended to clarify whether a lung nodule is suspicious or likely benign, potentially reducing the need for risky and costly invasive diagnostic procedures.

Rule out malignancy in lung nodules



Every year, more than

1.6 million

people will be identified with having a suspicious lung nodule,1 and many will undergo invasive diagnostic procedures such as a lung biopsy.

1 in 5

of these diagnostic procedures results in a complication.2

We need a

better way

to understand which patients can avoid unnecessary diagnostic procedures.

About

DetermaDx

DetermaDx utilizes a proprietary immune system interrogation approach to measure gene expression changes that signal the presence of absence of cancer.

Why

DetermaDx

Rule out malignancy in lung nodules.

Identification

Order DetermaRx for your patient with stage I or IIA non-squamous NSCLC undergoing resection.

Complications

We analyze the molecular signature of your patient’s tumor tissue to stratify your patient’s risk.

Cost

Make informed treatment decisions for your patient following surgery.

Immune Response

for Nodule Evaluation (IRENE)

  • Ongoing clinical validation study with more than 2400 subjects
  • 62 sites including both academic and community practices
  • Largest reported cohort with pulmonary nodules 5-30 mm representative of U.S. patient population

Tanner N, Dickinson K, Hesterberg L, Ross D, Copeland K. (2020). Diagnostic evaluation of pulmonary nodules in the IRENE (Immune Response for Nodule Evaluation) Cohort: A comparison of practice settings. American Journal of Respiratory and Critical Care Medicine. 201:A4727. – View Abstract


Hesterberg L, Dickinson K, Friedman L, Sheibani N, McQuary P, et al. (2019). The immune response for nodule evaluation (IRENE) cohort profile. Poster presented at CHEST Annual Meeting, New Orleans, LA. – View Poster

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References

  1. Gould, et al. (2015) Recent trends in the identification of incidental pulmonary nodules. American Journal of Respiratory and Critical Care Medicine 192:1206.
  2. Huo, et al. (2019) Complication rates and downstream medical costs associated with invasive diagnostic procedures for lung abnormalities in the community setting. JAMA Internal Medicine 179:324.
  3. National Lung Screening Trial Research Team. (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. New England Journal of Medicine 365:395.
  4. Tanner, et al. (2015) Management of pulmonary nodules by community pulmonologists: A multicenter observational study. Chest 148:1405.